Measurement of pH near dissolving enteric coatings.

  title={Measurement of pH near dissolving enteric coatings.},
  author={Abizer I Harianawala and Robin H. Bogner and Michael Bradley},
  journal={International journal of pharmaceutics},
  volume={247 1-2},
Previous authors have predicted the pH at the surface of enteric coatings using mathematical models. The purpose of our work is to experimentally determine the pH. A modified laser spectrometer was constructed to excite fluorescein in the medium above a dissolving enteric coating--hydroxypropylmethylcellulose phthalate (HP) in buffer (pH 6.5 and 7.0) in the… CONTINUE READING