Measurement of oxygen tension within mesenchymal stem cell spheroids.


Spheroids formed of mesenchymal stem cells (MSCs) exhibit increased cell survival and trophic factor secretion compared with dissociated MSCs, making them therapeutically advantageous for cell therapy. Presently, there is no consensus for the mechanism of action. Many hypothesize that spheroid formation potentiates cell function by generating a hypoxic core… (More)
DOI: 10.1098/rsif.2016.0851