Measurement of oxidatively induced DNA damage and its repair, by mass spectrometric techniques

  title={Measurement of oxidatively induced DNA damage and its repair, by mass spectrometric techniques},
  author={M. Dizdaroglu and E. Coşkun and P. Jaruga},
  journal={Free Radical Research},
  pages={525 - 548}
  • M. Dizdaroglu, E. Coşkun, P. Jaruga
  • Published 2015
  • Chemistry, Medicine
  • Free Radical Research
  • Abstract Oxidatively induced damage caused by free radicals and other DNA-damaging agents generate a plethora of products in the DNA of living organisms. There is mounting evidence for the involvement of this type of damage in the etiology of numerous diseases including carcinogenesis. For a thorough understanding of the mechanisms, cellular repair, and biological consequences of DNA damage, accurate measurement of resulting products must be achieved. There are various analytical techniques… CONTINUE READING
    The current state of eukaryotic DNA base damage and repair
    • 114
    • PDF
    Human Biomonitoring of DNA Adducts by Ion Trap Multistage Mass Spectrometry
    • 7
    Strategies for the evaluation of DNA damage and repair mechanisms in cancer
    • 20
    • Highly Influenced
    • PDF


    Publications referenced by this paper.
    Free radical-induced damage to DNA: mechanisms and measurement.
    • 797
    Oxidatively generated base damage to cellular DNA.
    • 379
    Mechanisms of free radical-induced damage to DNA
    • 332
    Quantitative determination of oxidative base damage in DNA by stable isotope‐dilution mass spectrometry
    • 140
    Urinary 8-hydroxy-2'-deoxyguanosine as a biological marker of in vivo oxidative DNA damage.
    • 651
    • PDF
    DNA base damage by reactive oxygen species, oxidizing agents, and UV radiation.
    • 371
    • PDF