Measurement of nonsulfated cholecystokinins.

@article{Agersnap2014MeasurementON,
  title={Measurement of nonsulfated cholecystokinins.},
  author={Mikkel Agersnap and Jens Frederik Rehfeld},
  journal={Scandinavian journal of clinical and laboratory investigation},
  year={2014},
  volume={74 5},
  pages={
          424-31
        }
}
Most proteins undergo posttranslational modifications that govern the function of the protein. In synchrony, correspondingly unmodified proteins that are functionally silent or act differently may also be synthesized. The gut hormone precursor, procholecystokinin (proCCK) is an example of a protein that is heavily modified. An essential modification is O-sulfation of Y₇₇, which is necessary for the gallbladder emptying effect of CCK peptides via the CCKA-receptor. In order to examine possible… CONTINUE READING
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