Measurement of nonsulfated cholecystokinins

@article{Agersnap2014MeasurementON,
  title={Measurement of nonsulfated cholecystokinins},
  author={Mikkel Askj{\ae}r Agersnap and Jens F Rehfeld},
  journal={Scandinavian Journal of Clinical and Laboratory Investigation},
  year={2014},
  volume={74},
  pages={424 - 431}
}
  • M. AgersnapJ. Rehfeld
  • Published 1 August 2014
  • Biology
  • Scandinavian Journal of Clinical and Laboratory Investigation
Abstract Most proteins undergo posttranslational modifications that govern the function of the protein. In synchrony, correspondingly unmodified proteins that are functionally silent or act differently may also be synthesized. The gut hormone precursor, procholecystokinin (proCCK) is an example of a protein that is heavily modified. An essential modification is O-sulfation of Y77, which is necessary for the gallbladder emptying effect of CCK peptides via the CCKA-receptor. In order to examine… 

20th International Symposium on Regulatory Peptides (REGPEP2014)

  • Á.
  • Biology
    Journal of Molecular Neuroscience
  • 2014
This study reveals that a substantial part of intestinal CCK is non-sulfated, but only little occurs in the brain, which may be due to a longer lasting posttranslational maturation process in neurons.

Analysis of enteroendocrine cell populations in the human colon

It is concluded that enteroendocrine cells of the human colon, like those of other regions and species, exhibit overlapping patterns of hormone colocalisation and that the hormones and their patterns of expression differ between human and other species.

Distribution and characterisation of CCK containing enteroendocrine cells of the mouse small and large intestine

It is concluded that authentic, biologically active, CCK occurs in EEC of the mouse large intestine.

Cholecystokinin expression in tumors: biogenetic and diagnostic implications.

An overview of the cell-specific biogenesis of CCK peptides, and a description of the CCK expression in tumors and of the cholecystokininoma syndrome are presented.

The uncovering and characterization of a CCKoma syndrome in enteropancreatic neuroendocrine tumor patients

A CCKoma syndrome with severe hypersecretion of CCK exists in man and the duodenal ulcer disease and diarrhea with permanently low gastrin in plasma suggest that CCKomas may mimic gastrinoma-like symptoms, because CCK peptides are full agonists of the gastrin/CCK-B receptor.

The distribution and chemical coding of enteroendocrine cells in Trypanosoma cruzi-infected individuals with chagasic megacolon

The data suggests that the denervation and associated chronic inflammation are accompanied by changes in the number and coding of EEC that could contribute to disorders of motility and defence in the chagasic megacolon.

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