Measurement of membrane rigidity on trapped unilamellar phospholipid vesicles by using differential confocal microscopy.

@article{Liu2011MeasurementOM,
  title={Measurement of membrane rigidity on trapped unilamellar phospholipid vesicles by using differential confocal microscopy.},
  author={Tze-Hsuan Liu and Jian-Long Xiao and Chau-Hwang Lee and J. Lin},
  journal={Applied optics},
  year={2011},
  volume={50 19},
  pages={3311-5}
}
We use optical tweezers to trap a unilamellar phospholipid vesicle and measure the out-of-plane thermal fluctuations by using differential confocal microscopy. Bending moduli of the lipid membranes are calculated directly from the mean-square values of the fluctuation amplitudes. Owing to the refractive index contrast between the inner and outer solutions of the vesicle, optical tweezers trap the vesicle laterally and improve the reliability of the measured fluctuation amplitudes along the… CONTINUE READING

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