Measurement of mechanical forces generated by skin fibroblasts embedded in a three-dimensional collagen gel.

@article{Delvoye1991MeasurementOM,
  title={Measurement of mechanical forces generated by skin fibroblasts embedded in a three-dimensional collagen gel.},
  author={P Delvoye and P Wiliquet and Jean Luc L{\'e}v{\^e}que and Betty V. Nusgens and Charles Maurice Lapiere},
  journal={The Journal of investigative dermatology},
  year={1991},
  volume={97 5},
  pages={898-902}
}
Mechanical activities developed by cells play a significant role in the embryogenesis, development, and physiopathology of pluricellular organisms. A technique is described to measure in vitro the traction force developed by cells seeded into a three-dimensional polymeric collagen lattice. It is based on the use of strain gauges generating an electrical signal upon tension that is amplified and recorded. The intensity of the signal depends on the number and type of cells, cytoskeleton integrity… CONTINUE READING

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