Measurement of invasive potential provides an accurate prognostic marker for giant cell tumour of tendon sheath.

@article{Grover1998MeasurementOI,
  title={Measurement of invasive potential provides an accurate prognostic marker for giant cell tumour of tendon sheath.},
  author={Rajiv Grover and Adriaan O. Grobbelaar and Paul I Richman and Paul J. Smith},
  journal={Journal of hand surgery},
  year={1998},
  volume={23 6},
  pages={728-31}
}
Giant cell tumours of tendon sheath vary from solitary nodules to a multinodular variety that exhibits local infiltration. Recent advances in molecular oncology have defined a gene, nm23, expressed in normal cells which is responsible for inhibiting infiltration. The aim of this study was to investigate the expression of nm23 in a series of 52 giant cell tumours using immunohistochemistry and to assess its prognostic potential. nm23 expression was absent in 21%, of tumours and this was… CONTINUE READING

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This immunohistochemical test for nm23 is easily performed on standard paraffin sections and is recommended as an accurate prognostic marker for giant cell tumours of tendon sheath .
Giant cell tumours of tendon sheath vary from solitary nodules to a multinodular variety that exhibits local infiltration .
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