Measurement of intrinsic properties of amyloid fibrils by the peak force QNM method.

  title={Measurement of intrinsic properties of amyloid fibrils by the peak force QNM method.},
  author={Jozef Adamcik and C{\'e}cile Lara and Ivan Usov and Jae Sun Jeong and Francesco Simone Ruggeri and Giovanni Dietler and Hilal A Lashuel and Ian W Hamley and Raffaele Mezzenga},
  volume={4 15},
We report the investigation of the mechanical properties of different types of amyloid fibrils by the peak force quantitative nanomechanical (PF-QNM) technique. We demonstrate that this technique correctly measures the Young's modulus independent of the polymorphic state and the cross-sectional structural details of the fibrils, and we show that values for amyloid fibrils assembled from heptapeptides, α-synuclein, Aβ(1-42), insulin, β-lactoglobulin, lysozyme, ovalbumin, Tau protein and bovine… CONTINUE READING
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