Measurement of interstitial cetirizine concentrations in human skin: correlation of drug levels with inhibition of histamine-induced skin responses.

Abstract

BACKGROUND The purpose of the present study was to measure the concentrations of cetirizine in the extracellular water compartment in intact human skin and assess simultaneously inhibition of histamine-induced wheal and flare reactions. METHODS Skin cetirizine levels were collected by the microdialysis technique and analyzed by high-pressure liquid… (More)

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