Measurement of interleukin 8 in combination with C-reactive protein reduced unnecessary antibiotic therapy in newborn infants: a multicenter, randomized, controlled trial.

@article{Franz2004MeasurementOI,
  title={Measurement of interleukin 8 in combination with C-reactive protein reduced unnecessary antibiotic therapy in newborn infants: a multicenter, randomized, controlled trial.},
  author={Axel Franz and Karl Bauer and Andreas Schalk and Suzanne Marie Garland and Ellen D Bowman and Kerstin Rex and Calle Nyholm and Mikael Norman and Adel Bougatef and Martina Kron and Walter Andreas Mihatsch and Frank Pohlandt},
  journal={Pediatrics},
  year={2004},
  volume={114 1},
  pages={1-8}
}
OBJECTIVE Neonatal bacterial infections carry a high mortality when diagnosed late. Early diagnosis is difficult because initial clinical signs are nonspecific. Consequently, physicians frequently prescribe antibiotic treatment to newborn infants for fear of missing a life-threatening infection. This study was designed to test the hypotheses that a diagnostic algorithm that includes measurements of interleukin 8 (IL-8) and C-reactive protein (CRP) 1) reduces antibiotic therapy and 2) does not… CONTINUE READING

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