Measurement of insulin-like growth factor binding protein-1 in cervical/vaginal secretions: comparison with the ROM-check Membrane Immunoassay in the diagnosis of ruptured fetal membranes.

@article{Rutanen1993MeasurementOI,
  title={Measurement of insulin-like growth factor binding protein-1 in cervical/vaginal secretions: comparison with the ROM-check Membrane Immunoassay in the diagnosis of ruptured fetal membranes.},
  author={E. M. Rutanen and Fredrika Pekonen and Tommi K{\"a}rkk{\"a}inen},
  journal={Clinica chimica acta; international journal of clinical chemistry},
  year={1993},
  volume={214 1},
  pages={73-81}
}
Insulin-like growth factor binding protein-1 (IGFBP-1) is a major protein in amniotic fluid. In this study, we evaluated the diagnostic potential of IGFBP-1 measurement in cervical/vaginal secretions as an indicator of ruptured fetal membranes. Data were also compared with those obtained by the ROM-check Membrane Immunoassay (Adeza Biochemical, Sunnyvale, California) that is based on the detection of fetal fibronectin in vaginal fluid. In women with intact membranes and not in labor, the… CONTINUE READING

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