Measurement of in vivo Endocardial and Hepatic Convective Heat Transfer Coefficient


vi Chapter 1 Introduction 1 Chapter 2 Measuring endocardial convective heat transfer coefficient: 17 Measuring system and in vitro experiments Chapter 3 Minimizing blood deposition through heparin−carbon coating on 43 the surface of catheter sensors for in vivo measurement of the endocardial convective heat transfer coefficient Chapter 4 In vivo measurement of swine endocardial convective heat transfer 64 coefficient Chapter 5 In vivo measurement of swine hepatic convective heat transfer 89 coefficient Appendix A Correlation between the endocardial h and the heart rate 111 Appendix B How to measure blood velocity using a hot film sensor system 122 ii ACKNOWLEDGEMENT I would like to state my deepest gratitude to my advisor, for giving me an opportunity to work with him, for his invaluable guidance and for helping me get through this dissertation. I could not have done it without his help. Biomedical Sciences for conducting many pig experiments for my in vivo measurements. I would also like to thank him for many invaluable suggestions he made to my experiments and my dissertation. Without his help, this work would have been impossible. valuable suggestion on the theoretical calculations and the in vitro experiments of my research. for his help and suggestions. Madison for conducting many in vivo experiments in the hospital for more precise measurements. Haemmerich for their very helpful suggestions and encouragement. I thank all my friends for their help and encouragement. Finally, I would like to express my deepest appreciation to my family, especially my mother who has always supported me in every way, and to all my siblings for their help and encouragement. iv ABSTRACT The convective heat transfer coefficient (h) is a measure of how well heat transfers from a solid surface to a fluid (gas or liquid) by convection. The coefficient is a function of the fluid, the flow field, the geometry of the surface, and its thermal boundary condition. Endocardial convective heat transfer coefficients and hepatic convective heat transfer coefficients are needed for the simulation of heat loss from tissue to blood flow in the cardiac chambers and in the large vessels of the liver. This simulation of heat loss is needed for finite element method (FEM) modeling of radiofrequency cardiac catheter ablation, radiofrequency hepatic probe ablation and hepatic cryoablation in order to study and improve ablation probes and methods. Radiofrequency cardiac catheter ablation has been successfully used for the treatment of many forms of …

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@inproceedings{Tangwongsan2003MeasurementOI, title={Measurement of in vivo Endocardial and Hepatic Convective Heat Transfer Coefficient}, author={Chanchana Tangwongsan and John G. Webster and Willis J. Tompkins and Patrick V. Farrell and Dorin Panescu and Jeffrey S. Schowalter and Kenneth L. Meredith and David M. Mahvi and Jang-Zern Tsai}, year={2003} }