Measurement of homocysteine and other aminothiols in plasma: advantages of using tris(2-carboxyethyl)phosphine as reductant compared with tri-n-butylphosphine.

@article{Krijt2001MeasurementOH,
  title={Measurement of homocysteine and other aminothiols in plasma: advantages of using tris(2-carboxyethyl)phosphine as reductant compared with tri-n-butylphosphine.},
  author={Jakub Krijt and Marie Vackov{\'a} and Viktor Ko{\vz}ich},
  journal={Clinical chemistry},
  year={2001},
  volume={47 10},
  pages={
          1821-8
        }
}
BACKGROUND Aminothiols have been implicated in the pathogenesis of arteriosclerosis, and reliable methods are needed to determine their concentrations in body fluids. We present a comparison of two analytical methods and focus on the reduction of low-molecular weight and protein-mixed disulfides of homocysteine, cysteine, cysteinyl-glycine, and glutathione. METHODS The plasma total aminothiol profile was determined by HPLC with fluorescence detection after derivatization with ammonium 7… CONTINUE READING

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