Measurement of free drug in phase I: is it useful?

Abstract

Early investigation of protein binding of a new drug is mandatory. The following questions have to be answered: is unbound fraction constant over tested concentrations? Which proteins are involved? What are the binding parameters? Can the drug compete with other therapeutic agents for the binding sites or in other words can drug displacements be predicted… (More)

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@article{Barr1990MeasurementOF, title={Measurement of free drug in phase I: is it useful?}, author={J{\'e}r{\^o}m{\'e} Barr{\'e} and P. Riant and J. P. Tillement}, journal={Fundamental & clinical pharmacology}, year={1990}, volume={4 Suppl 2}, pages={141s-150s} }