Measurement of fibrinogen concentrations in suspensions of washed rabbit and human platelets by radioimmunoassays.

@article{Harfenist1985MeasurementOF,
  title={Measurement of fibrinogen concentrations in suspensions of washed rabbit and human platelets by radioimmunoassays.},
  author={E J Harfenist and Jeffrey L. Wrana and Marian A. Packham and James Fraser Mustard},
  journal={Thrombosis and haemostasis},
  year={1985},
  volume={53 1},
  pages={110-5}
}
Although fibrinogen is a cofactor in platelet aggregation, washed rabbit platelets aggregate when stimulated with ADP even when no fibrinogen is added to the platelet suspension. Washed human platelets usually do not aggregate to a significant extent when stimulated with ADP unless fibrinogen is added. To study this phenomenon, radioimmunoassays for rabbit and human fibrinogens have been developed and used to measure fibrinogen concentrations in suspensions of washed platelets. The fibrinogen… CONTINUE READING