Corpus ID: 17989726

Measurement of exogenous gamma-hydroxybutyric acid ( GHB ) in urine using isotope ratio mass spectrometry ( IRMS )

@inproceedings{Lott2015MeasurementOE,
  title={Measurement of exogenous gamma-hydroxybutyric acid ( GHB ) in urine using isotope ratio mass spectrometry ( IRMS )},
  author={Susanne Lott and T. Piper and Lena-Maria Mehling and A. Spottke and A. Maas and M. Thevis and B. Madea and C. Hess},
  year={2015}
}
  • Susanne Lott, T. Piper, +5 authors C. Hess
  • Published 2015
  • Aim: The objective of the study was to check if gas chromatography/combustion/isotope ratio mass spectrometry (GC/C/IRMS) is a suitable method to differentiate between endogenous and exogenous GHB in urine. Methods: In the presented study, a controlled and monitored administration of 2.25 g GHB (Xyrem) to one participant was carried out. Spot urine samples were collected once before administration and at different time intervals after the intake (2 h; 4 h; 6 h; 8 h; 12 h; 24 h; 48 h and 72 h… CONTINUE READING
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    Differentiation of endogenous and exogenous γ-Hydroxybutyrate in rat and human urine by GC/C/IRMS

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