Measurement of daily cholesterol synthesis rates in man by assay of the fractional conversion of mevalonic acid to cholesterol.

@article{McNamara1977MeasurementOD,
  title={Measurement of daily cholesterol synthesis rates in man by assay of the fractional conversion of mevalonic acid to cholesterol.},
  author={Donald J. McNamara and Edward H. Ahrens and Paul Samuel and John Robert Crouse},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1977},
  volume={74 7},
  pages={
          3043-6
        }
}
A significant correlation has been found in man between total daily cholesterol synthesis rates as determined by sterol balance measurements and the fraction of intravenously administered R-[5-14C]mevalonic acid converted to cholesterol. In 30 studies it was found that the mean daily cholesterol synthesis rates estimated by sterol balance measurements ranged from 395 to 3047 mg/day, whereas the fractional conversion of mevalonate to cholesterol varied from 0.28 to 0.99. The two parameters… CONTINUE READING

From This Paper

Topics from this paper.