Measurement of current‐voltage relations in the membrane of the giant axon of Loligo

@article{Hodgkin1952MeasurementOC,
  title={Measurement of current‐voltage relations in the membrane of the giant axon of Loligo},
  author={Alan Lloyd Hodgkin and Andrew Fielding Huxley and Bernhard Katz},
  journal={The Journal of Physiology},
  year={1952},
  volume={116}
}
The importance of ionic movements in excitable tissues has been emphasized by a number of recent experiments. On the one hand, there is the finding that the nervous impulse is associated with an inflow of sodium and an outflow of potassiuim (e.g. Rothenberg, 1950; Keynes & Lewis, 1951). On the other, there are experiments which show that the rate of rise and amplitude of the action potential are determined by the concentration of sodium in the external medium (e.g. Hodgkin & Katz, 1949 a… Expand

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References

SHOWING 1-10 OF 17 REFERENCES
The dual effect of membrane potential on sodium conductance in the giant axon of Loligo
This paper contains a further account of the electrical properties of the giant axon of Loligo. It deals with the 'inactivation' process which gradually reduces sodium permeability after it hasExpand
Currents carried by sodium and potassium ions through the membrane of the giant axon of Loligo
TLDR
The identity of the ions which carry the various phases of the membrane current is chiefly concerned with sodium ions, since there is much evidence that the rising phase of the action potential is caused by the entry of these ions. Expand
Studies on permeability in relation to nerve function, ionic movements across exonal membranes.
TLDR
Studies on the permeability of the surface membranes of the giant axon of Squid to K indicate that a dynamic rather than a static equilibrium exists at rest, which indicates that there are important energy yielding chemical reactions involved in the exchange of ions across the membrane at rest. Expand
The effect of temperature on the electrical activity of the giant axon of the squid
TLDR
It is important to know whether the characteristic relation between action potential and resting potential holds over a wide range of temperature, and the use of an internal recording electrode facilitates this study. Expand
ELECTRIC IMPEDANCE OF THE SQUID GIANT AXON DURING ACTIVITY
  • K. Cole, H. Curtis
  • Materials Science, Medicine
  • The Journal of general physiology
  • 1939
TLDR
The transverse impedance and the conductance are closely associated properties of the membrane, and their sudden changes constitute, or are due to, the activity which is responsible for the all-or-none law and the initiation and propagation of the nerve impulse. Expand
A quantitative description of membrane current and its application to conduction and excitation in nerve
TLDR
This article concludes a series of papers concerned with the flow of electric current through the surface membrane of a giant nerve fibre by putting them into mathematical form and showing that they will account for conduction and excitation in quantitative terms. Expand
TRANSVERSE ELECTRIC IMPEDANCE OF THE SQUID GIANT AXON
  • H. Curtis, K. Cole
  • Materials Science, Medicine
  • The Journal of general physiology
  • 1938
TLDR
It has been found that the axon membrane has a polarization impedance with an average phase angle of 76° and an average capacity of 1.1µf./cm2 at 1 kilocycle. Expand
Effect of potassium and sodium on resting and action potentials of single myelinated nerve fibres
TLDR
The present paper deals with the changes in resting and action potential that occurred under these conditions under a new method for measuring membrane potentials in isolated myelinated nerve fibres of the frog. Expand
The Sheath Components of the Giant Nerve Fibres of the Squid
Recent analysis of the ultrastructure of the sheaths of vertebrate nerve fibres has revealed that from the largest, heavily myelinated to the smallest, so-called unmyelinated fibres the molecularExpand
MEMBRANE AND PROTOPLASM RESISTANCE IN THE SQUID GIANT AXON
TLDR
The direct current longitudinal resistance of the squid giant axon was measured as a function of the electrode separation and the inter-electrode length was immersed in oil. Expand
...
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