Measurement of changes in high-energy phosphates in the cardiac cycle using gated 31P nuclear magnetic renonance.

@article{Fossel1980MeasurementOC,
  title={Measurement of changes in high-energy phosphates in the cardiac cycle using gated 31P nuclear magnetic renonance.},
  author={Eric T Fossel and Howard E. Morgan and Joanne S. Ingwall},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1980},
  volume={77 6},
  pages={3654-8}
}
Levels of the high-energy phosphate-containing compounds, ATP and creatine phosphate, and of inorganic phosphate (Pi) were measured as a function of position in the cardiac cycle. Measurements were made on isolated, perfused, working rat hearts through the use of gated 31P nuclear magnetic resonance spectroscopy. Levels of ATP and creatine phosphate were found to vary during the cardiac cycle and were maximal at minimal aortic pressure and minimal at maximal aortic pressure. Pi varied inversely… CONTINUE READING