Measurement of c-myc oncogene expression provides an accurate prognostic marker for acral lentiginous melanoma.

Abstract

Acral lentiginous melanoma is a particularly aggressive tumour with a worse prognosis than other varieties of primary cutaneous melanoma. In order to study the biology of this disease, the activity of the c-myc oncogene was studied in tumours from 45 patients using flow cytometry. High levels of oncoprotein were found in all tumours and exceeded that… (More)

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