Measurement of bone degradation products in serum using antibodies reactive with an isomerized form of an 8 amino acid sequence of the C-telopeptide of type I collagen.

@article{Bonde1997MeasurementOB,
  title={Measurement of bone degradation products in serum using antibodies reactive with an isomerized form of an 8 amino acid sequence of the C-telopeptide of type I collagen.},
  author={Marianne Bonde and Patrick Garnero and Christian Fledelius and Per Qvist and Pierre Dominique Delmas and Claus Christiansen},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={1997},
  volume={12 7},
  pages={1028-34}
}
An enzyme-linked immunosorbent assay for measuring type I collagen degradation products in serum (S-ELISA) was developed. The assay uses a high affinity polyclonal antibody which reacts with an isomerized form of an 8 amino acid sequence of the C-telopeptides of type I collagen (EKAHD-beta-GGR). Cross-reactivity to a nonisomerized synthetic peptide form of the 8 amino acid sequence is less than 0.2%. Values obtained in a group of premenopausal women (age, 33.3 +/- 3.11 years) were 69 +/- 24 ng… CONTINUE READING
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