Measurement of benzene oxide in the blood of rats following administration of benzene.

  title={Measurement of benzene oxide in the blood of rats following administration of benzene.},
  author={Andrew B. Lindstrom and Karen Yeowell-O'Connell and Suramya Waidyanatha and Bernard T Golding and Rogelio Tornero-Velez and Stephen M. Rappaport},
  volume={18 8},
Although it is generally assumed that metabolism of benzene proceeds through an initial step involving oxidation to benzene oxide (BO) by CYP450 in the liver, the production of BO has never been unambiguously confirmed in animals dosed with benzene. Furthermore, prevailing hypotheses of the mechanism by which benzene causes cancer have ignored the possibility that BO might play a direct role, despite the fact that BO is electrophilic, binds covalently to cell macromolecules and is presumably… CONTINUE READING
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