Measurement of atropisomer racemization kinetics using segmented flow technology.

@article{Davoren2012MeasurementOA,
  title={Measurement of atropisomer racemization kinetics using segmented flow technology.},
  author={Jennifer E Davoren and Mark W. Bundesmann and Qi T Yan and Elizabeth M Collantes and Scot Mente and Deane M Nason and David L F Gray},
  journal={ACS medicinal chemistry letters},
  year={2012},
  volume={3 5},
  pages={433-5}
}
When stable atropisomers are encountered by drug discovery teams, they can have important implications due to potential differences in their biological activity, pharmacokinetics, and toxicity. Knowledge of an atropisomer's activation parameters for interconversion is required to facilitate informed decisions on how to proceed. Herein, we communicate the… CONTINUE READING