Measurement of apoptosis and proliferation of bone marrow plasma cells in patients with plasma cell proliferative disorders.

@article{Witzig1999MeasurementOA,
  title={Measurement of apoptosis and proliferation of bone marrow plasma cells in patients with plasma cell proliferative disorders.},
  author={Thomas E Witzig and Michael A. Timm and Dirk Larson and Terry M. Therneau and Philip R. Greipp},
  journal={British journal of haematology},
  year={1999},
  volume={104 1},
  pages={131-7}
}
The proliferative rate of malignant plasma cells, as measured by the plasma cell labelling index (PCLI), is an important prognostic factor in multiple myeloma (MM); however, the PCLI alone is probably Inadequate to describe tumour growth because it ignores the idea that myeloma cells may have a reduced rate of apoptosis. The aims of this study were to develop a flow cytometric method to measure the apoptosis index of fresh marrow plasma cells and develop a plasma cell growth index (PCGI) that… CONTINUE READING