Measurement of an explosive behavior in the mouse, induced by MK-801, a PCP analogue.

@article{Deutsch1993MeasurementOA,
  title={Measurement of an explosive behavior in the mouse, induced by MK-801, a PCP analogue.},
  author={Stephen I. Deutsch and Ana Hitri},
  journal={Clinical neuropharmacology},
  year={1993},
  volume={16 3},
  pages={251-7}
}
MK-801, a noncompetitive antagonist of the N-methyl-D-aspartate (NMDA) receptor complex that binds with high-affinity to the phencyclidine (PCP) binding site, stimulated an outbred strain of NIH Swiss mice to display discrete episodes of explosive jumping behavior, designated as "popping." The episodes of this behavior were characterized with respect to their dose dependency, latency, and duration. The number of mice displaying this behavior increased with increasing doses of MK-801. The… CONTINUE READING

Citations

Publications citing this paper.

Similar Papers

Loading similar papers…