Measurement of amyloid peptide precursor of Alzheimer disease in human blood by double antibody immunoradiometric assay.

Abstract

The dementia of Alzheimer disease (AD) correlates with the deposition of extracellular amyloid, and this amyloid arises from the abnormal processing of a high molecular weight amyloid peptide precursor (APP), which is a normal cellular protein that is found in both brain and in peripheral tissues in humans. Overproduction of the APP in AD could cause… (More)

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