Measurement of alpha4beta2 nicotinic acetylcholine receptors with [123I]5-I-A-85380 SPECT.

@article{Fujita2000MeasurementOA,
  title={Measurement of alpha4beta2 nicotinic acetylcholine receptors with [123I]5-I-A-85380 SPECT.},
  author={Masahiro Fujita and Gilles Tamagnan and Sami S. Zoghbi and Mohammed S. Al-Tikriti and Ronald M. Baldwin and John P. Seibyl and Robert B. Innis},
  journal={Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  year={2000},
  volume={41 9},
  pages={1552-60}
}
UNLABELLED Nicotinic acetylcholine receptors (nAChRs) play an important role in tobacco dependence and a potential therapeutic role in neuropsychiatric disorders such as Alzheimer's disease. [123I]5-iodo-3-[2(S)-2-azetidinylmethoxy]pyridine (5-I-A-85380) is a new SPECT tracer that labels alpha4beta2 nAChRs. The purpose of this study was to assess the… CONTINUE READING