Measurement of allergenic potency using the local lymph node assay.

@article{Basketter2001MeasurementOA,
  title={Measurement of allergenic potency using the local lymph node assay.},
  author={David A Basketter and G. Frank Gerberick and I A N Kimber},
  journal={Trends in pharmacological sciences},
  year={2001},
  volume={22 6},
  pages={
          264-5
        }
}
Chemicals that can act as contact allergens have been identified successfully using guinea-pig models. However, contact allergy is still common, probably because of, at least in part, failures of risk assessment. A new method, the local lymph node assay, replaces the guinea-pig as a tool for hazard identification and offers the real prospect of accurate prediction of allergen potency, the missing link in skin sensitization risk assessment. 
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Statement on the validity of the local lymph node assay for skin sensitization testing

  • I. Kimber, R. J. Dearman
  • 2000

Use of the local lymph node assay for the estimation of relative contact allergenic potency

  • G. F. Gerberick
  • Contact Derm .
  • 2000

A comparison of statistical approaches to derivation of EC 3 values from local lymph node assay dose responses

  • R. J. Dearman
  • J . Appl . Toxicol .
  • 1999

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