Measurement of Th1, Th2 cytokines and white cell count in childhood haemoglobinopathies with uncomplicated malaria infection

@article{Tatfeng2012MeasurementOT,
  title={Measurement of Th1, Th2 cytokines and white cell count in childhood haemoglobinopathies with uncomplicated malaria infection},
  author={Youtchou Tatfeng and Dennis Edo Agbonlahor and O. F. Amegor},
  journal={Hematology},
  year={2012},
  volume={17},
  pages={47 - 50}
}
Abstract Background/objective: The relative balance between Th1 and Th2 cytokines appears crucial in the outcome of infections. We assayed the levels of some proinflammatory Th1 cytokines, interleukin-2 (IL-2) and interferon-gamma (IFN-gamma), and anti-inflammatory Th2 cytokines, IL-4 and IL-10 in homozygous haemoglobin (Hb) AA, heterozygous HbAS-genotyped and sickle cell (HbSS) individuals with uncomplicated Plasmodium falciparum malaria. Methods: Levels of Th1 and Th2 cytokines of 111… 
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References

SHOWING 1-10 OF 27 REFERENCES
In vivo production of type 1 cytokines in healthy sickle cell disease patients.
TLDR
The results revealed comparable circulating levels of all type 1 cytokines in both healthy sickle cell disease and normal control subjects, with the exception of in vivo sIL-2R production.
Interferon production in sickle cell disease.
TLDR
Results indicate that a significant percentage of SCD patients in both the steady state and infectious state associated with crisis, have impaired gamma IFN production, which may be another factor to explain the increased frequency and severity of infections in SCD.
Serum Levels of Substance P Are Elevated in Patients With Sickle Cell Disease and Increase Further During Vaso-Occlusive Crisis
TLDR
Serum levels of SP were elevated in all SCD patients and were highest in patients in pain crisis, implying that SP plays a prominent role in the pain and inflammation of SCD and may be a measurable laboratory marker of vaso-occlusive crisis.
Levels of Tumor Necrosis Factor α/Cachectin (TNFα) in Sera from Patients with Sickle Cell Disease
TLDR
Serum levels of tumor necrosis factor α/cachectin (TNFα) were studied in a group of adult patients with sickle cell disease (SCD) and an inverse correlation was observed between the percentages of Hb F and the levels of TNFα found in the sera from the patients.
Activated monocytes and platelet-monocyte aggregates in patients with sickle cell disease.
TLDR
It is concluded that there are increased circulating PMAs and monocyte activation in patients with SCD, as defined by intracellular expression of these cytokines.
Elevated immunoreactive tumor necrosis factor and interleukin-1 in sickle cell disease.
TLDR
It is concluded that plasma TNF is frequently elevated in subjects with sickle cell disease, and IL-1 is also elevated in some subjects, and a direct role for these cytokines in the pathogenesis of vascular occlusion in sicklecell disease was not demonstrated.
Levels of tumor necrosis factor alpha/cachectin (TNF alpha) in sera from patients with sickle cell disease.
TLDR
Serum levels of tumor necrosis factor alpha/cachectin (TNF alpha) were studied in a group of adult patients with sickle cell disease and an inverse correlation was observed between the percentages of Hb F and the levels of TNF alpha found in the sera from the patients.
Increased susceptibility of malaria-infected variant erythrocytes to the mononuclear phagocyte system.
TLDR
Increased susceptibility to phagocytosis of infected erythrocytes was found for a number of genetic variants involving the alpha-globin chain, and oxidative damage from hydrogen peroxide led to much more effective killing of parasites in glucose-6-phosphate dehydrogenase-deficient ery Throcytes than in normal ones.
Tumor necrosis factor alpha in children with sickle cell disease in stable condition.
TLDR
It is indicated that most children with SCD in stable condition have normal TNF-alpha concentrations and that those with high T NF-alpha levels are more likely to have growth deficits.
Laboratory profile of sickle cell disease: a cross-sectional analysis. The Cooperative Study of Sickle Cell Disease.
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