Measurement of Pre-Existing IgG and IgM Antibodies against Polyethylene Glycol in Healthy Individuals.

@article{Chen2016MeasurementOP,
  title={Measurement of Pre-Existing IgG and IgM Antibodies against Polyethylene Glycol in Healthy Individuals.},
  author={Bing-Mae Chen and Yu-cheng Su and Chia-Jung Chang and Pierre-Alain Burnouf and Kuo-Hsiang Chuang and Chien-Hsiun Chen and Tian-Lu Cheng and Yuan-Tsong Chen and Jer-Yuarn Wu and Steve R Roffler},
  journal={Analytical chemistry},
  year={2016},
  volume={88 21},
  pages={
          10661-10666
        }
}
Polyethylene glycol (PEG) is a biocompatible polymer that is often attached to therapeutic molecules to improve bioavailability and therapeutic efficacy. Although antibodies with specificity for PEG may compromise the safety and effectiveness of PEGylated medicines, the prevalence of pre-existing anti-PEG antibodies in healthy individuals is unclear. Chimeric human anti-PEG antibody standards were created to accurately measure anti-PEG IgM and IgG antibodies by direct ELISA with confirmation by… CONTINUE READING

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