Measurement of Pre-Existing IgG and IgM Antibodies against Polyethylene Glycol in Healthy Individuals.

@article{Chen2016MeasurementOP,
  title={Measurement of Pre-Existing IgG and IgM Antibodies against Polyethylene Glycol in Healthy Individuals.},
  author={B. Chen and Y. Su and Chia-Jung Chang and Pierre-Alain Burnouf and Kuo-Hsiang Chuang and Chien-Hsiun Chen and T. Cheng and Y. Chen and J. Wu and S. Roffler},
  journal={Analytical chemistry},
  year={2016},
  volume={88 21},
  pages={
          10661-10666
        }
}
Polyethylene glycol (PEG) is a biocompatible polymer that is often attached to therapeutic molecules to improve bioavailability and therapeutic efficacy. Although antibodies with specificity for PEG may compromise the safety and effectiveness of PEGylated medicines, the prevalence of pre-existing anti-PEG antibodies in healthy individuals is unclear. Chimeric human anti-PEG antibody standards were created to accurately measure anti-PEG IgM and IgG antibodies by direct ELISA with confirmation by… Expand
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  • 4
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  • M. McSweeney, L. L. Price, +14 authors S. Lai
  • Chemistry, Medicine
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  • 2019
  • 7
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 47 REFERENCES
A double antigen bridging immunogenicity ELISA for the detection of antibodies to polyethylene glycol polymers.
  • 50
Anti-PEG immunity: emergence, characteristics, and unaddressed questions.
  • Q. Yang, S. Lai
  • Medicine
  • Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology
  • 2015
  • 209
Anti-PEG IgM elicited by injection of liposomes is involved in the enhanced blood clearance of a subsequent dose of PEGylated liposomes.
  • 271
...
1
2
3
4
5
...