Measurement of Placental Alpha-Microglobulin-1 in Cervicovaginal Discharge to Diagnose Rupture of Membranes

@article{Lee2007MeasurementOP,
  title={Measurement of Placental Alpha-Microglobulin-1 in Cervicovaginal Discharge to Diagnose Rupture of Membranes},
  author={Si Eun Lee and Joong-Shin Park and Errol R. Norwitz and Kunwoo Kim and Hyun Soo Park and Jong Kwan Jun},
  journal={Obstetrics \& Gynecology},
  year={2007},
  volume={109},
  pages={634-640}
}
OBJECTIVE: To compare the accuracy of an immunoassay to measure levels of placental alpha-microglobulin-1 in cervicovaginal secretions with that of conventional clinical assessment for the diagnosis of rupture of membranes. METHODS: A prospective observational study was performed in consecutive patients with signs or symptoms of rupture of membranes at Seoul National University Hospital from March 2005 to February 2006. Initial evaluation included both the standard clinical evaluation for… 

Placental α-microglobulin-1 to detect uncertain rupture of membranes in a European cohort of pregnancies

AT was more sensitive compared to clinical assessment, independent of the examiners experience and gestational age, and seems to be a cost-effective approach in the assessment of these patients with uncertain ROM.

Comparison of placental alpha microglobulin-1 in vaginal fluid with intra-amniotic injection of indigo carmine for the diagnosis of rupture of membranes

The PAMG-1 immunoassay in vaginal fluid yielded results that were comparable to those of the instillation of indigo carmine into the amniotic cavity; therefore, it is proposed that PAMg-1 is a sensitive and specific test to assess ROM in patients with an equivocal diagnosis based on simple tests.

The accuracy of placental alpha-microglobuline-1 test in diagnosis of premature rupture of the membranes

The accuracy of PAMG-1 test was superior to both Fern and Nitrazine test in PROM diagnosis and was shown to be more accurate than conventional tests such as Fern test.

COMPARISON BETWEEN PLACENTAL ALPHA MICROGLOBULIN 1 (AMNISURE) RAPID IMMUNOASSAY AND STANDARD CLINICAL METHOD FOR DIAGNOSIS OF PREMATURE RUPTURE OF MEMBRANES IN IDO EKITI

Placental alpha-microglobulin-1 immunoassay is a rapid and accurate method for confirming the diagnosis of rupture of membrane and was superior to conventional standard diagnostic methods.

Diagnostic performance of placental alpha-microglobulin-1 test in women with prolonged pre-labour rupture of membranes

  • G. ElejeE. Ezugwu C. Ezeama
  • Medicine
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
  • 2016
This study in women with prolonged PROM, confirms that PAMG-1 test has high diagnostic accuracy irrespective of the duration of PROM before clinical evaluation.

Placental alpha microglobulin-1 (AmniSure® test) for detection of premature rupture of fetal membranes

Detection of the PAMG-1 in the vaginal fluid using AmniSure® test is an accurate method to diagnose rupture of the fetal membranes, with high sensitivity, specificity, negative and positive predictive values.

Placental Alpha Microglobulin-1 Detection in Cervico-vaginal Secretions in the Diagnosis of Preterm Premature Rupture of The Membranes

The value of detection of placental alpha macroglobulin-1 in cervicovaginal discharge as a diagnostic test for Premature Rupture of Membranes (PROM) compared with traditional methods was evaluated.

Amnisure: A point of care diagnostic for preterm, term prelabor rupture of membranes

The aim was to determine efficacy of AmniSure rapid immunoassay placental alpha-microglobulin-1 test for accurate diagnosis of true ROM in women with watery discharge after 28 weeks gestation, compare with conventional methods.

Novel markers for the diagnosis of premature rupture of membrane in pregnancy: urea, creatinine and prolactin of vaginal fluid

  • R. GargA. Nigam
  • Medicine
    International Journal of Clinical Obstetrics and Gynaecology
  • 2019
Prolactin has more diagnostic value than urea and creatinine in detecting PROM, and can be used in suspected cases, and was the best in predicting PROM.
...

References

SHOWING 1-10 OF 32 REFERENCES

AmniSure placental alpha microglobulin-1 rapid immunoassay versus standard diagnostic methods for detection of rupture of membranes.

The purpose of this study was to compare the AmniSure rapid immunoassay with standard methods for diagnosing rupture of fetal membranes and found it to be highly accurate in diagnosing fetal membrane rupture.

Diagnostic power of the vaginal washing-fluid prolactin assay as an alternative method for the diagnosis of premature rupture of membranes

  • E. E. BuyukbayrakC. TuranO. UnalR. DansukB. Cengizoğlu
  • Medicine
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
  • 2004
The optimal diagnostic cut-off value for vaginal washing-fluid prolactin level determination was found to be 30 µIU/ml with 95% sensitivity, 78% specificity, 84% positive predictive value, 93% negative predictivevalue, 87% accuracy and 11.30 relative risk.

Value of the fern test to confirm or reject the diagnosis of ruptured membranes is modest in nonlaboring women presenting with nonspecific vaginal fluid loss.

It is concluded that the fern test should be granted supportive rather than conclusive value in diagnosing ruptured membranes in nonlaboring women presenting with nonspecific vaginal fluid loss.

Prolonged rupture of membranes in the term newborn.

A conservative clinical approach utilizing blood cultures and CBC evaluations in the management of PROM is warranted, asPROM is associated with significantly increased incidence of positive blood cultures.

Impact of oligohydramnios on maternal and perinatal outcomes of spontaneous premature rupture of the membranes at 18-28 weeks.

After adjusting for confounding variables, neonates with oligohydramnios are twice as likely to develop pulmonary hypoplasia and more likely to experience neonatal death when compared to those with adequate fluid, even though the difference is not statistically significant.

Ferning of Amniotic Fluid Contaminated With Blood

The presence of blood may alter the morphology of the fern, but does not act as a contaminant that would affect the accuracy of the test.

Clinical significance of intra-amniotic inflammation in patients with preterm premature rupture of membranes.