Measurement of Placental Alpha-Microglobulin-1 in Cervicovaginal Discharge to Diagnose Rupture of Membranes

@article{Lee2007MeasurementOP,
  title={Measurement of Placental Alpha-Microglobulin-1 in Cervicovaginal Discharge to Diagnose Rupture of Membranes},
  author={S. Lee and Joong-Shin Park and E. Norwitz and Kunwoo Kim and H. Park and J. Jun},
  journal={Obstetrics \& Gynecology},
  year={2007},
  volume={109},
  pages={634-640}
}
OBJECTIVE: To compare the accuracy of an immunoassay to measure levels of placental alpha-microglobulin-1 in cervicovaginal secretions with that of conventional clinical assessment for the diagnosis of rupture of membranes. METHODS: A prospective observational study was performed in consecutive patients with signs or symptoms of rupture of membranes at Seoul National University Hospital from March 2005 to February 2006. Initial evaluation included both the standard clinical evaluation for… Expand

Paper Mentions

Observational Clinical Trial
This is a prospective observational trial that will enroll pregnant women between 24 and 36 6/7 weeks of gestation that present with signs and symptom of preterm labor with clinically… Expand
ConditionsPreterm Birth, Preterm Labour
InterventionDevice
Observational Clinical Trial
To show that having less qualified personnel (non-Laboratory trained professionals) perform the test yields the same result as if a Laboratory trained professional performed the test… Expand
ConditionsRupture of Fetal Membranes
InterventionDevice
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The PAMG-1 immunoassay in vaginal fluid yielded results that were comparable to those of the instillation of indigo carmine into the amniotic cavity; therefore, it is proposed that PAMg-1 is a sensitive and specific test to assess ROM in patients with an equivocal diagnosis based on simple tests. Expand
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The accuracy of PAMG-1 test was superior to both Fern and Nitrazine test in PROM diagnosis and was shown to be more accurate than conventional tests such as Fern test. Expand
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This study in women with prolonged PROM, confirms that PAMG-1 test has high diagnostic accuracy irrespective of the duration of PROM before clinical evaluation. Expand
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