Measurement of Myelin in the Preterm Brain: Multi-compartment Diffusion Imaging and Multi-component T2 Relaxometry

@article{Melbourne2013MeasurementOM,
  title={Measurement of Myelin in the Preterm Brain: Multi-compartment Diffusion Imaging and Multi-component T2 Relaxometry},
  author={Andrew Melbourne and Zach Eaton-Rosen and Alan Bainbridge and Giles S. Kendall and Manuel Jorge Cardoso and Nicola J. Robertson and Neil Marlow and S{\'e}bastien Ourselin},
  journal={Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention},
  year={2013},
  volume={16 Pt 2},
  pages={336-44}
}
Measurements of myelination and indicators of myelination status in the preterm brain could be predictive of later neurological outcome. Quantitative imaging of myelin could thus serve to develop predictive biomarkers; however, accurate estimation of myelin content is difficult. In this work we show that measurement of the myelin water fraction (MWF) is achievable using widely available pulse sequences and state-of-the-art algorithmic modelling of the MR imaging. We show results of myelin water… CONTINUE READING

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