Measurement of MMP-9 and -12 degraded elastin (ELM) provides unique information on lung tissue degradation

@inproceedings{SkjtArkil2012MeasurementOM,
  title={Measurement of MMP-9 and -12 degraded elastin (ELM) provides unique information on lung tissue degradation},
  author={Helene Skj\ot-Arkil and Rikke Elgaard Clausen and Quoc Hai Trieu Nguyen and Yaguo Wang and Qinlong Zheng and Fernando J Martinez and Cory M Hogaboam and Meilan Han and Lloyd B Klickstein and Martin R Larsen and Arkadiusz Nawrocki and Diana Julie Leeming and Morten Asser Karsdal},
  booktitle={BMC pulmonary medicine},
  year={2012}
}
BACKGROUND Elastin is an essential component of selected connective tissues that provides a unique physiological elasticity. Elastin may be considered a signature protein of lungs where matrix metalloprotease (MMP) -9-and -12, may be considered the signature proteases of the macrophages, which in part are responsible for tissue damage during disease progression. Thus, we hypothesized that a MMP-9/-12 generated fragment of elastin may be a relevant biochemical maker for lung diseases. METHODS… CONTINUE READING
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