Measurement of 4 urinary C-18 oxygenated corticosteroids by stable isotope dilution mass fragmentography.

@article{Ulick1991MeasurementO4,
  title={Measurement of 4 urinary C-18 oxygenated corticosteroids by stable isotope dilution mass fragmentography.},
  author={Stanley Ulick and C K Chan and Jennifer Z. Wang},
  journal={The Journal of steroid biochemistry and molecular biology},
  year={1991},
  volume={38 1},
  pages={59-66}
}
The cortisol C-18 oxidation pathway leading to the production of 18-hydroxy- and 18-oxocortisol is expressed in adenomatous primary aldosteronism and glucocorticoid remediable aldosteronism. In order to better define the significance of the pathway and its usefulness in differential diagnosis, we have developed a stable isotope dilution mass fragmentographic method for the determination of the tetrahydro metabolites of aldosterone, 18-hydroxycorticosterone and 18-oxocortisol and of… CONTINUE READING
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