Measurement and perturbation of morphogen lifetime: effects on gradient shape.

  title={Measurement and perturbation of morphogen lifetime: effects on gradient shape.},
  author={Jeffrey A. Drocco and Oliver Grimm and David W. Tank and Eric F. Wieschaus},
  journal={Biophysical journal},
  volume={101 8},
Protein lifetime is of critical importance for most biological processes and plays a central role in cell signaling and embryonic development, where it impacts the absolute concentration of signaling molecules and, potentially, the shape of morphogen gradients. Early conceptual and mathematical models of gradient formation proposed that steady-state gradients are established by an equilibration between the lifetime of a morphogen and its rates of synthesis and diffusion, though whether… CONTINUE READING
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