Corpus ID: 33619791

Measurement and partial characterization of an interleukin-2 inhibitor (IL-2-IN) in human urine.

@article{Fleischmann1990MeasurementAP,
  title={Measurement and partial characterization of an interleukin-2 inhibitor (IL-2-IN) in human urine.},
  author={Jonathan Fleischmann and S M Acino and K M Thomas and D J Riden and D B Wentworth and Zahra Toossi and Jerrold J. Ellner},
  journal={Journal of biological regulators and homeostatic agents},
  year={1990},
  volume={4 2},
  pages={
          73-80
        }
}
We observed a human urine-derived protein complex (IL-2-IN) which competitively inhibits interleukin-2 (IL-2) dependent murine lymphocyte proliferation. Measurements of urinary IL-2-IN have been used to stratify the immune response of patients to bacteria in the bladder. Partial characterization of IL-2-IN indicates that it is a heat-stable, 75 kDa complex comprised of interleukin-2 bound to another protein(s). Although the IL-2-IN complex is stable in physiologic buffers, the complex can be… Expand
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