Measured and estimated glomerular filtration rate: current status and future directions

  title={Measured and estimated glomerular filtration rate: current status and future directions},
  author={Andrew S. Levey and Josef Coresh and Hocine Tighiouart and Tom Greene and Lesley A. Inker},
  journal={Nature Reviews Nephrology},
Evaluation of glomerular filtration rate (GFR) is central to the assessment of kidney function in medical practice, research and public health. Measured GFR (mGFR) remains the reference standard, but the past 20 years have seen major advances in estimated GFR (eGFR). Both eGFR and mGFR are associated with error compared with true GFR. eGFR is now recommended by clinical practice guidelines, regulatory agencies and public health agencies for the initial evaluation of GFR, with measured GFR (mGFR… 

Improving Glomerular Filtration Rate Estimation—Across the Age and Diversity Spectrum

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Calculated estimated glomerular filtration rate (eGFR) is recommended using equations developed by the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) for adults ≥18 years and by the CKiD in Children for ages <18”years because they used readily available information.



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Methods for the evaluation of GFR estimating equations are discussed and topics addressed include statistical methods used in development and validation of equations; explanation of measures of performance used for evaluation, with focus on distinction between bias, precision and accuracy.

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It is hypothesized, and begun to test the hypothesis, that a panel of filtration markers (panel eGFR) from a single blood draw would require fewer demographic or clinical variables and could estimate GFR as accurately as measured GFR.

Measured GFR in Routine Clinical Practice-The Promise of Dried Blood Spots.

Examination of the current literature and data addressing GFR measurements by dried capillary blood spots and its potential application in high-risk groups finds it to be of concern in populations at high risk for kidney disease.

GFR estimation: from physiology to public health.

  • A. LeveyL. InkerJ. Coresh
  • Medicine, Biology
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The CKD-EPI (CKD Epidemiology Collaboration) equations are the most accurate GFR estimating equations that have been evaluated in large diverse populations and are applicable for general clinical use.

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The accuracy of GFR estimates did not change over time, and Clinicians should interpret changes in estimated GFR over time as reflecting changes in measured GFR rather than changes in errors in the GFR Estimates in most individuals.

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The purpose of this study was to develop an equation from MDRD Study data that could improve the prediction of GFR from serum creatinine concentration, and major clinical decisions in general medicine, geriatrics, and oncology are made by using the Cockcroft-Gault formula and other formulas to predict the level of renal function.

A new equation to estimate glomerular filtration rate.

The CKD-EPI creatinine equation is more accurate than the Modification of Diet in Renal Disease Study equation and could replace it for routine clinical use.

Estimated Glomerular Filtration Rate; Laboratory Implementation and Current Global Status.

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