Measles viruses possessing the polymerase protein genes of the Edmonston vaccine strain exhibit attenuated gene expression and growth in cultured cells and SLAM knock-in mice.

@article{Takeda2008MeaslesVP,
  title={Measles viruses possessing the polymerase protein genes of the Edmonston vaccine strain exhibit attenuated gene expression and growth in cultured cells and SLAM knock-in mice.},
  author={Makoto Takeda and Shinji Ohno and Maino Tahara and Hiroki Takeuchi and Yuta Shirogane and Hirofumi Ohmura and Takafumi Nakamura and Yusuke Yanagi},
  journal={Journal of virology},
  year={2008},
  volume={82 23},
  pages={11979-84}
}
Live attenuated vaccines against measles have been developed through adaptation of clinical isolates of measles virus (MV) in various cultured cells. Analyses using recombinant MVs with chimeric genomes between wild-type and Edmonston vaccine strains indicated that viruses possessing the polymerase protein genes of the Edmonston strain exhibited attenuated viral gene expression and growth in cultured cells as well as in mice expressing an MV receptor, signaling lymphocyte activation molecule… CONTINUE READING
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