Measles virus suppresses RIG-I-like receptor activation in dendritic cells via DC-SIGN-mediated inhibition of PP1 phosphatases.

@article{Mesman2014MeaslesVS,
  title={Measles virus suppresses RIG-I-like receptor activation in dendritic cells via DC-SIGN-mediated inhibition of PP1 phosphatases.},
  author={A. W. Mesman and Esther M. Zijlstra-Willems and Tanja M. Kaptein and R. D. de Swart and M. E. Davis and M. Ludlow and W. P. Duprex and Michaela U. Gack and S. Gringhuis and T. Geijtenbeek},
  journal={Cell host & microbe},
  year={2014},
  volume={16 1},
  pages={
          31-42
        }
}
  • A. W. Mesman, Esther M. Zijlstra-Willems, +7 authors T. Geijtenbeek
  • Published 2014
  • Biology, Medicine
  • Cell host & microbe
  • Dendritic cells (DCs) are targets of measles virus (MV) and play central roles in viral dissemination. However, DCs express the RIG-I-like receptors (RLRs) RIG-I and Mda5 that sense MV and induce type I interferon (IFN) production. Given the potency of this antiviral response, RLRs are tightly regulated at various steps, including dephosphorylation by PP1 phosphatases, which induces their activation. We demonstrate that MV suppresses RIG-I and Mda5 by activating the C-type lectin DC-SIGN and… CONTINUE READING
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