Measles virus replication in lymphatic cells and organs of CD150 (SLAM) transgenic mice.

@article{Welstead2005MeaslesVR,
  title={Measles virus replication in lymphatic cells and organs of CD150 (SLAM) transgenic mice.},
  author={G. Grant Welstead and Caterina Iorio and Ryan Draker and Jane Bayani and Jeremy Squire and Sompong Vongpunsawad and Roberto B Cattaneo and Christopher D. Richardson},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2005},
  volume={102 45},
  pages={16415-20}
}
A transgenic mouse containing the complete human SLAM (hSLAM/CD150) gene, including its endogenous promoter for transcription, was generated by using human genomic DNA cloned into a bacterial artificial chromosome. hSLAM, the primary receptor for measles viruses (MV), was expressed on activated B, T, and dendritic cells with an expression profile equivalent to that of humans. We demonstrated that hSLAM(+) cells obtained from the transgenic mouse, including activated B, T, and dendritic cells… CONTINUE READING

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