Measles virus infection of thymic epithelium in the SCID-hu mouse leads to thymocyte apoptosis.

@article{Auwrter1996MeaslesVI,
  title={Measles virus infection of thymic epithelium in the SCID-hu mouse leads to thymocyte apoptosis.},
  author={P. Auw{\"a}rter and Hideto Kaneshima and Joseph M McCune and Georg Wiegand and Diane E Griffin},
  journal={Journal of virology},
  year={1996},
  volume={70 6},
  pages={3734-40}
}
Mortality from measles is caused mostly by secondary infections associated with the depression of cellular immunity. The mechanism of immune suppression and the role of virus strain differences on the immune system are incompletely understood. SCID-hu mice were used to determine the effects of virulent, wild-type (Chicago-1) and avirulent, vaccine (Moraten) strains of measles virus (MV) on the human thymus in vivo. Chicago-1 replicated rapidly, with a 100-fold decrease in numbers of thymocytes… CONTINUE READING

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