Measles antibody titers of multiple sclerosis patients and their siblings

@article{Brody1972MeaslesAT,
  title={Measles antibody titers of multiple sclerosis patients and their siblings},
  author={Jacob A. Brody and John L. Sever and A H Edgar and James McNEW},
  journal={Neurology},
  year={1972},
  volume={22},
  pages={492 - 492}
}
Results of numerous investigations indicate that measles antibody titer is slightly but consistently higher in multiple sclerosis (MS) patients than in controls (references listed in the appendix). Previously we reported titers to measles and several other viral antigens to be higher in MS patients than in controls but not higher than in their siblings of the same sex.’ j2 Since MS is not recognized as a familial disease, this result was ~ n e x p e c t e d . ~ We designed the present study to… 

Measles antibodies as related to HL‐A types in multiple sclerosis

It is suggested that HL-A antigens are linked to one of the factors that determines measles antibody titers in multiple sclerosis patients.

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The antibody levels to measles were highest in all study groups in that area in Finland for which the population has the highest relative risk to contract multiple sclerosis, and no correlation could be found between the antibody levels and different clinical variables.

Cellular Immunology in Multiple Sclerosis Response to Several Viruses

Several groups, including the authors' own, have found slightly increased measles antibody levels in MS patients, and the association of measles and an unidentified agent with MS is suggested.

Antibodies against three different structural components of measles virus in patients with multiple sclerosis, their siblings and matched controls.

Patients with multiple sclerosis, their siblings and controls matched for age, sex and place of residence were tested for antibodies to measles virus hemagglutinin (HI), hemolysin (HLI) and

Measles antibodies and histocompatibility types in multiple sclerosis

Characterization of the Virus Antibody Activity of Oligoclonal IgG Produced in the Central Nervous System of Patients with Multiple Sclerosis

Increased antibody titers in multiple sclerosis patients are highly likely to represent a true antibody response to measles and not a cross reaction to some other antigen, according to the results of a study carried out together with Finnish colleagues.

Measles virus antibodies in multiple sclerosis. Comparison of antibody titers in cerebrospinal fluid and serum.

Serum and cerebrospinal fluid samples were collected from groups of 30 patients with multiple sclerosis, no known somatic disease, or other neurological disorders and moderately increased total CSF protein content, and significantly reduced ratios of measles virus hemagglutination-inhibiting or nucleocapsid complement-fixing antibodies or both were found.

Epstein-Barr virus antibodies in multiple sclerosis.

Findings support the contention that patients with multiple sclerosis have a general aberration of the immunological system and there was no association between antibody titers and duration or activity of the disease.

Multiple sclerosis

Increased levels of measles antibody in serum were demonstrated in MS patients, but there was no difference in these patients' cellular immunity to measles virus versus that of the controls, and there wasno abnormality of cellular immunity against the other viruses tested.

ANTIBODIES AGAINST DIFFERENT VIRAL ANTIGENS IN CEREBROSPINAL FLUID OF PATIENTS WITH MULTIPLE SCLEROSIS AND OTHER NEUROLOGICAL DISEASES

The results suggest that anti‐body production against structural components of measles virus and rubella virus occurs in the central nervous system of some MS patients.
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References

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Measles antibody titers in multiple sclerosis patients, siblings, and controls.

The results confirm other reports that MS patients have slightly higher titers to measles antigens than unrelated controls, but siblings, however, had titers as high as those encountered among MS patients, suggesting that the elevation was a familial phenomenon.

MULTIPLE SCLEROSIS: A REAPPRAISAL

A thorough knowledge of the normal is essential to the practising neuroradiologist, and this book should be read and digested by all students of the subject.

Application of a microtechnique to viral serological investigations.

  • J. Sever
  • Biology
    Journal of immunology
  • 1962
A microtechnique (modified Takatsy) is described which can be applied to complement fixation, hemagglutination, hemagenesis inhibition and metabolic inhibition tests andComparative data obtained with the micro- and standard systems establish the reliability and validity of the microsystem.

Measles antibodies in m u l t i p l e sclerosis

  • Proc SOC Exp Biol Med
  • 1962