Measles Virus Infection in a Transgenic Model Virus-Induced Immunosuppression and Central Nervous System Disease

  title={Measles Virus Infection in a Transgenic Model Virus-Induced Immunosuppression and Central Nervous System Disease},
  author={Michael B. A. Oldstone and H. Andy Podgurski Michael Lewicki and Diane Thomas and Antoinette Tishon and Samuel Dales and John Patterson and Mari Manchester and Dirk Homann and Denise Naniche and Andreas Holz},
Measles virus (MV) infects 40 million persons and kills one million per year primarily by suppressing the immune system and afflicting the central nervous system (CNS). The lack of a suitable small animal model has impeded progress of understanding how MV causes disease and the development of novel therapies and improved vaccines. We tested a transgenic mouse line in which expression of the MV receptor CD46 closely mimicked the location and amount of CD46 found in humans. Virus replicated in… CONTINUE READING
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