Measles: Not just a childhood rash

@article{Sabella2010MeaslesNJ,
  title={Measles: Not just a childhood rash},
  author={Camille Sabella},
  journal={Cleveland Clinic Journal of Medicine},
  year={2010},
  volume={77},
  pages={207 - 213}
}
  • C. Sabella
  • Published 1 March 2010
  • Medicine
  • Cleveland Clinic Journal of Medicine
In recent years, the number of US measles cases has increased, and outbreaks in adults continue to be reported in communities with a high number of unvaccinated people. These trends underscore the need for high overall measles vaccination coverage, and for physicians to entertain the diagnosis of measles in adult patients with a febrile illness and rash. Outbreaks continue to be reported in communities with a high number of unvaccinated people. Most cases are linked to international travel. 

Figures from this paper

Measles 101

TLDR
Being clinically up-to-date about measles should be helpful, especially for American physicians who completed their training and/or practiced only in recent years.

Atypical measles syndrome in adults: still around

TLDR
Doctors should be aware of the atypical measles syndrome presentation in patients without previous measles immunisation in order to limit the delay of diagnosis, to avoid unnecessary investigations and to prevent the potential spread of this infectious disease.

Measles Induced Death in Eastеrn Europe

TLDR
Two cases of a measles-type infection with a fatal outcome for two children - 4 and 11 years of age respectively - who had not been immunized by the time of the event and who developed an unfolding clinical picture with the respective complications are presented.

Epidemiology of Measles in Sudan

TLDR
The review established that it is crucial to enforce coordination between governmental and non-governmental agencies for an effective disease surveillance system in the area, especially in those affected by civil wars.

An evaluation of the clinical features of measles virus infection for diagnosis in children within a limited resources setting

TLDR
The combination of fever, maculopapular rash, and hyperpigmented rash can be used as a screening tool regarding measles infection in an outbreak setting, which can then be confirmed by anti-measles Ig M.

Evaluation of a Community Health Worker Intervention on Rates of Measles, Mumps and Rubella Immunization in a Somali Population in Lexington, Nebraska

TLDR
There is MMR vaccine specific hesitancy within the Somali population in Lexington, Nebraska that puts the community at risk for a measles outbreak, and using a community health worker intervention can help to improve MMR immunization rates within this population.

A comparison of adult and pediatric measles patients admitted to emergency departments during the 2008-2011 outbreak in the Midi-Pyrénées region of France.

TLDR
A retrospective study of adult and pediatric measles patients admitted to three tertiary-level university hospitals between January 2008 and May 2011 found that hospitalized pediatric patients differed from adults in terms of disease severity and complications.

Renal dysfunction in adults during measles.

Dermatological Signs and Symptoms of Measles: A Prospective Case Series and Comparison with the Literature

TLDR
Dermatological manifestations do not seem conclusive in the clinical data set as well as in the literature, and the exact onset of the Koplik spots should be further explored in detail.
...

References

SHOWING 1-10 OF 43 REFERENCES

The clinical significance of measles: a review.

TLDR
Complication rates are higher in those <5 and >20 years old, although croup and otitis media are more common in those<2 years old and encephalitis in older children and adults.

Immunization Safety Review: Measles-Mumps-Rubella Vaccine and Autism

TLDR
In the United States, immunization programs have resulted in the eradication of smallpox, the elimination of polio, and the control and near-elimination of other oncecommon, often debilitating, and potentially life-threatening diseases, including measles, mumps, rubella, diphtheria, pertussis, tetanus, and Haemophilus influenzae type b.

Measles outbreak in a pediatric practice: airborne transmission in an office setting.

TLDR
An outbreak of measles in a pediatric practice in DeKalb County, GA in February 1981 supports the fact that measles virus when it becomes airborne can survive at least one hour, and suggests that airborne spread is unusual.

Persistence of measles virus and depression of antibody formation in patients with giant-cell pneumonia after measles.

TLDR
Results of studies of 4 leukemic children with overt measles complicated by severe pneumonitis indicate that the presumptive diagnosis of this condition can be made and supplement the evidence already obtained for measles virus in cases of giant-cell pneumonia without clinically apparent measles.

Airborne transmission of measles in a physician's office.

An unusual outbreak of measles occurred in 1982 in a pediatrician's office in Muskegon, Mich. Three children, who had arrived at the office 60 to 75 minutes after a child with measles had departed,

Coinfection is common in measles-associated pneumonia.

TLDR
In MAP, coinfection with other microbes is common and cyanosis and a respiratory rate of > or = 60/min predict a greater risk of dying.

Atypical measles syndrome: unusual hepatic, pulmonary, and immunologic aspects

TLDR
Three unusual manifestations of the atypical measles syndrome are highlighted: 1) transient hepatitis, 2) persistence of pulmonary lesions for several years, and 3) occurrence of excessively high measles hemagglutination-inhibition antibody titers.

Reported vaccine-preventable diseases--United States, 1993, and the childhood immunization initiative.

  • Medicine
    MMWR. Morbidity and mortality weekly report
  • 1994
TLDR
Provisional surveillance data for 1993 indicate that for five of these diseases and for congenital rubella syndrome (CRS), the number of reported cases is at or near the lowest levels ever, suggesting near interruption of transmission ofThese 10 diseases.

Pediatric emergency room visits: a risk factor for acquiring measles.

TLDR
To evaluate whether emergency room visits were a risk factor for acquiring measles, patients in Los Angeles and Houston were enrolled in case-control studies and records were reviewed to determine whether case patients and control patients had visited the emergency room during the period of potential measles exposure.