Meaningful design and contrast estimability in FMRI

@article{Smith2007MeaningfulDA,
  title={Meaningful design and contrast estimability in FMRI},
  author={Stephen M. Smith and Mark Jenkinson and Christian F. Beckmann and Karla L. Miller and Mark W. Woolrich},
  journal={NeuroImage},
  year={2007},
  volume={34},
  pages={127-136}
}
Optimising the efficiency of an experimental design is known to be of great importance. However, existing methods for calculating design rank deficiency and contrast estimability (an important aspect of experimental design) relate to computational precision rather than image noise and are therefore not very meaningful. For example, a contrast between two experimental conditions may be mathematically "estimable" while requiring a huge differential BOLD response for statistical significance to be… CONTINUE READING
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