Mean xenograft survival of 14.6 days in a small group of hDAF-transgenic pig hearts transplanted orthotopically into baboons.

@article{Brenner2005MeanXS,
  title={Mean xenograft survival of 14.6 days in a small group of hDAF-transgenic pig hearts transplanted orthotopically into baboons.},
  author={Paolo Brenner and Michael Schmoeckel and Cosmas Damian Wimmer and V{\'e}ronique Eder and Alexander Rucker and Thomas W. Felbinger and Sunji Uchita and Marty Hinz and Ulrike Brandl and Bruno M. Meiser and Hermann C Reichenspurner and Claus R Hammer and B. W. Carney G. N. Cecil C. R. Evans H. J. Karwowski Reichart},
  journal={Transplantation proceedings},
  year={2005},
  volume={37 1},
  pages={472-6}
}
INTRODUCTION In a discordant orthotopic xenotransplantation model (pig-to-baboon) donor pigs expressing human decay accelerating factor (hDAF) as a regulator of complement activity were used to prevent hyperacute xenograft rejection (HXR). We investigated a modified immunosuppressive therapy consisting of ERL080 (Novartis Pharma AG, Base, Switzerland), cyclosporin A (Neoral), steroids, and a cyclophosphamide (CyP) induction protocol with several reduced doses to prevent acute vascular rejection… CONTINUE READING