Mealtime glucose regulation with nateglinide in healthy volunteers: comparison with repaglinide and placebo.

OBJECTIVE This study was designed to compare the pharmacodynamic effects of single doses of nateglinide (A-4166), repaglinide, and placebo on mealtime insulin secretion and glycemic control in healthy subjects. RESEARCH DESIGN AND METHODS Fifteen healthy volunteers participated in this open-label five-period crossover study. They received single 10-min… (More)