Meal and oral glucose tests for assessment of beta -cell function: modeling analysis in normal subjects.

@article{Mari2002MealAO,
  title={Meal and oral glucose tests for assessment of beta -cell function: modeling analysis in normal subjects.},
  author={Andrea Mari and Ole Schmitz and Amalia Gastaldelli and Torben Oestergaard and Birgit Nyholm and Ele Ferrannini},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2002},
  volume={283 6},
  pages={E1159-66}
}
We investigated beta-cell function and its relationship to insulin sensitivity in 17 normal volunteers. For insulin secretion (derived by C-peptide deconvolution), a mathematical model was applied to 24-h triple-meal tests (MT) as well as oral glucose tolerance tests (OGTT); insulin sensitivity was assessed by the euglycemic insulin clamp technique. The beta-cell model featured a glucose concentration-insulin secretion dose response (characterized by secretion at 5 mM glucose and slope), a… CONTINUE READING
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