Meal-Induced Acceleration of Tablet Transit Through the Human Small Intestine

@article{Fadda2008MealInducedAO,
  title={Meal-Induced Acceleration of Tablet Transit Through the Human Small Intestine},
  author={Hala M. Fadda and Emma L. McConnell and Michael D. Short and Abdul W. Basit},
  journal={Pharmaceutical Research},
  year={2008},
  volume={26},
  pages={356-360}
}
The transit of dosage forms through the small intestine is considered to be constant at around 3 h, and unaffected by the presence of food. Here we address this assumption and examine how the timing of tablet and food administration can influence small intestine transit time. A non-disintegrating, radiolabelled tablet was given to ten healthy volunteers in a three-way crossover study using three different feeding regimens (1) fasted (tablet administered on an empty stomach and food withheld for… CONTINUE READING

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